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【化學生物學 & SFBC 系列報告會】Chemical Approaches to Decipher Histone Code

作者：管理員來源：本站發布日期:2014-05-06

報告題目：Chemical Approaches to Decipher Histone Code

報告人：Prof. Xiang David Li Department of Chemistry, The University of Hong Kong, Hong Kong

時間：2014年3月10日（周一），下午3:00

地點：化學院A區204/206

【Abstract】Histone posttranslational modifications (PTMs), such as phosphorylation, methylation and acetylation, play crucial roles in regulating many fundamental cellular processes, such as gene transcription, DNA replication, DNA damage repair, chromosome segregation and cell differentiation. Increasing evidences have indicated that PTMs of histones can serve as a heritable ‘code’ (so-called ‘histone code’), which provides epigenetic information that a mother cell can pass to its daughters. Histone code is ‘written’ or ‘erased’ by enzymes that generate or remove the modifications of histones. Meanwhile, ‘readers’ of histone code recognize specific histone modifications and ‘translate’ the code by executing distinct cellular programs necessary to establish the diverse cell phenotypes, while the genetic code (DNA) is unaltered.

While a large number of PTMs have been identified on various sites of histones, so far only a handful of them have been extensively studied. The cellular mechanisms and functions of many other PTMs, particularly those newly identified ones, remain essentially obscure. In this talk, I will present our chemical approaches to unravel biological significance of histone PTMs by identifying their substrates, ‘writers’, ‘erasers’ and ‘readers’.

【Brief Curriculum Vitae】

Xiang David Li, born 1981 in Kunming, China, received his B.Sc. in Chemistry at Fudan University in 2003, and Ph.D. in 2008 from The University of Hong Kong under the guidance of Professor Dan Yang. He has then spent three years as a postdoctoral fellow with Professor Tarun Kapoor at Rockefeller University. In 2011, he joined the University of Hong Kong as an Assistant Professor of Chemistry. His research interest is to develop chemical approaches to study protein posttranslational modifications.

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