劉志博

教授，博士生導師，國家傑出青年基金獲得者

放射性藥物化學·放射化學生物學

beat365 beat365
beat365 北大-清華生命科學聯合中心
電子信箱：zbliu@pku.edu.cn
課題組網站：http:/zliu/

研究興趣：

活體化學及其驅動的蛋白激活及藥物釋放；
罕見病的影像診斷探針及臨床轉化研究；
中子捕獲治療藥物及其輻射生物學效應;
新型醫用核素的生産工藝研究與臨床應用。

獎勵與榮譽:

2021, Best Preclinical Publication Award, the 9^th World ADC Annual Meeting
2021, Ones-to-Watch, Society of Nuclear Medicine and Molecular Imaging
2020, 中國化學會青年化學獎
2019, 藥明康德生命化學青年學者獎
2019, beat365青年教師教學基本功大賽一等獎
2018, Fairchild Award, 18th International Congress of Neutron Capture Therapy
2018, beat365綠葉生物青年科學家獎
2016, Distinguished Scientist Award, NIH-CSSA Committee
2015, Michael J. Welch Postdoctoral Award, Society of Nuclear Medicine and Molecular Imaging
2015, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
2015, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
2014, Edward Piers Memorial Award, Edward Piers Foundation
2014, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
2013, Young Investigator Award, 37th CASNMMI
2013, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation

代表性論文：

Qinyang Wang^#, Yupeng Wang^#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426
Zhibin Guo^#, Hanyu Hong^#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, doi: 10.1002/anie.202205014.
Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8,837
Jiyuan Li^#, Qi Sun^#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat Commun, 2022, 13, 2143
Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*, Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors, J. Am. Chem. Soc., 2022, doi.org/10.1021/jacs.2c02521
Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, Cationic Micelle as An In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 60, 19750–19758
Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255
Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552
Pu Zhang^#, Mengxin Xu^#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996
Mengxin Xu^#, Pu Zhang^#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2021, doi: 10.2967/jnumed.121.262533