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陳 鵬

 

 

特聘研究員,博士生導師, 化學生物學
電子信箱:pengchen#pku.edu.cn

 

教育與科研背景


2002 理學學士 beat365官方网站
2003 理學碩士 美國芝加哥大學 化學系
2007 理學博士 美國芝加哥大學 化學系
2007-2009 博士後,美國Scripps 研究所; 諾華制藥美國聖疊戈研發中心(GNF)
2009- 研究員,博士生導師,beat365官方网站
2011- 研究員,beat365合成與功能生物分子中心

 

研究領域與興趣


研究興趣主要集中在化學與生物學的前沿交叉領域,試圖通過化學家的知識與手段,為生命科學的探索提供一系列嶄新的工具和研究方式。

具體研究方向如下:

1.蛋白質工程,蛋白質特異标記,蛋白質藥物化學;
2.臨床感染性病菌與人體免疫系統相互作用的機理研究;
3.面向生物活體内的化學反應與技術;
4.金屬離子及有機小分子生物傳感器的開發與應用;

 

課題組網頁/chenpeng/ 

 

發表論文


2014

3. Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X and Chen P*. “Palladium-triggered Deprotection Chemistry for Protein Activation in Living Cells”, Nat. Chem. (2014), in print.

2. Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao B, Zeng S, Chen X, Chan J, He C* and Chen P*. “The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli”, Nat. Chem. Biol. (2014), 10, 21-8.

1. Fan Y, Zhao J, Yan Q, Chen P* and Zhao D*. “A Water-soluble Triscyclometalated Organoiridium Complex: Phosphorescent Nanoparticle Formation, Nonlinear Optics, and Application for Cell Imaging”,ACS Appl Mat. Inter. (2014) Epub ahead of print

2013

7. Lin S, Yan H, Li L, Yang M, Peng B, Chen S, Li W* and Chen P*, “Site-specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus”, Angew. Chem. Int. Ed. (2013),52, 13970-4.

6. Li J, Lin S, Wang J, Jia S, Yang M, Zhang X, Hao Z and Chen P* “Ligand-free Palladium-mediated Site-specific Protein Labeling inside Gram-negative Bacterial Pathogens”,J. Am. Chem. Soc. (2013) 135, 7330-8.

5. Zhao J, Lin S, Huang Y, Zhao J*, Chen P*. Mechanism-Based Design of a Photoactivatable Firefly Luciferase”, J. Am. Chem. Soc. (2013), 135, 7410-3

4. Ge X, Wang R, Ma J, Liu Y, Ezemaduka AN, Chen P, Fu X*, and Chang Z*. “DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli”, FEBS J. (2013) doi: 10.1111/febs.12701.

3. Chang H, Han M, Huang W, Wei G, Chen J, Chen P, Chen R, Zhang J, Xu T* and Xu P*. “Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans”, Protein Cell. (2013),4,883-6

2. Zhao BS, Zhang G, Zeng S, He C, and Chen P*. “Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator.”, Integr. Biol (2013), 5,1485-9.

1. Liu, J.; Karpus, J.;Wegner, S.; Chen P* and He C*. “Genetically Encoded Copper(I) Reporters with Improved Responses for Use in Imaging”, J. Am. Chem. Soc. (2013), 135:3144-3149.

2012

9. Yang, M.; Song, Y.; Zhang, M.; Lin, S.; Hao, Z.; Liang,Y.; Zhang, D. and Chen, P*.“Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity”, Angew. Chem. Int. Ed. (2012) 51, 7674-9.

8. Li, Y.; Yang, M.; Huang, Y.; Song, X.; Liu, L* and Chen, P*. “Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling”, Chem. Sci. (2012), 3, 2766-2770.

7. Li, J. and Chen, P*. "Moving Pd-mediated Protein Cross-coupling to Living Systems", ChemBioChem. (2012), 13, 1728-31.

6. Wang J, Karpus J, Zhao BS, Luo Z, Chen P and He C*. “A selective fluorescent probe for carbon monoxide imaging in living cells.” Angew. Chem. Int. Ed. (2012), 51, 9652-6.

5. Li, Y.; Yang, M.; Huang,Y.; Li, Y.; Chen, P*. and Liu, L*. “Ligation of Expressed Protein α-Hydrazides via Genetic Incorporation of an α-Hydroxy Acid.” ,ACS Chem. Biol. (2012), 7, 1015-1022.

4. Wei, W.; Zhu, T.;Wang, Y.; Yang, H.; Hao, Z.; Chen, P*. and Zhao, J*. “Engineering a gold-specific regulon for cell-basedvisual detection and recovery of gold”, Chem. Sci. (2012), 3, 1780-1784.

3. Liu, J.; Zhang, M. and Chen, P*. “Probing pH Mediated protein-protein interactions via photocrosslinking”, SCIENTIA SINICA Chimica. (2012) 42, 1694-1699.

2. Li, J.; Wang, J. and Chen, P*. “Unnatural amino acid mediated Protein Bioorthogonal Labeling” ,ACTA CHIMICA SINICA (2012),70, 1439-1445.

1. Chen, X.; Hao, Z.and Chen, P*. “Protein photocrosslinking reveals dimer of dimers formation on MarR protein in Escherichia coli”, SCIENCE CHINA Chemistry (2012). 42, 223-225.

2011

5. Lin, S.; Zhang, Z.; Xu, H.; Li, L.; Chen, S.; Li, J.; Hao,Z.; Chen, P*. “Site-specific incorporation of photocrosslinker and bioorthogonal amino acids into enteric bacterial pathogens”, J. Am. Chem. Soc. (2011), 133, 20581-7.

4. Zhang M, Lin S, Song X, Liu J, Fu Y, Fu X, Chang Z*, and Chen, P*. “A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance”, Nat. Chem. Biol. (2011), 7, 671-7. [This work is a “News Coverage” on Chem. & Eng. News. Sep 7, 2011,and has been highlighted by Nature Asia-Pacific on Sep 5, 2011 ]

3. Hao Z., Hong S., Chen X* and Chen, P*. “Introducing Bioorthogonal Functionalities into Proteins in Living Cells”, Acc. Chem. Res. (2011), 44, 742-51.

2. Hao, Z.; Song, Y.; Lin, S.; Yang, M.; Liang, Y.; Wang, J.; Chen, P*. “A readily synthesized cyclic pyrrolysine analogue for site-specific protein ‘click’ labeling”.Chem Commun (Camb) (2011). 47, 4502-4504.

1. Chen, P*.; Brugarolas P; and He, C*. “Redox Signaling in Human Pathogens”,Antioxid Redox. Signal. (2011), 14(6), 1107-18.

2010

Zhao, B.; Liang, Y.; Song, Y.; Zheng, C.; Hao, Z. and Chen, P*. “A Highly Selective Fluorescent Probe for Visualization of Organic Hydroperoxides in Living Cells”, J. Am. Chem. Soc. (2010). 132, 17065-7. 

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