羅海

博士, 副教授, 博士生導師

分析化學，質譜科學和技術

電話: +86-10-62751499

傳真: +86-10-62751708

電子信箱: hluo@pku.edu.cn

學術簡曆：

2000，美國普渡大學，分析化學，博士(導師：R. Graham Cooks, Michael J. Weaver)

1994，美國西弗吉尼亞大學，物理化學，碩士(導師：Naresh S. Dalal)

1990，中國科學技術大學，高分子化學，學士(導師：汪月生,張其錦)

2005 -至今，beat365官方网站，副教授

2002 - 2004，美國雅培公司生命研究中心，研究員

2000 - 2002，美國太平洋西北國家實驗室，博士後

1990 - 1992，中國科學院大連化學物理研究所，研習員

教學工作：

分析化學Seminar（研究生），分析化學（B）以及實驗課（本科生）

研究領域和興趣：

1. 質譜離子化技術和分析方法的發展及應用

2. 新型質譜離子源上的原位化學反應和應用

3. 非共價複合物和超分子團簇離子的氣相化學和表征

主持國家自然科學基金項目情況：

1. 國家自然科學基金面上項目，21874002，新型電化學-質譜平台及其在電化學反應機理研究中的應用，2019/01-2022/12，64萬元，在研

2. 國家自然科學基金應急管理項目，21445005，快速蒸發多通道旋轉質譜離子源的設計、構建和在生物組織診斷上的基礎應用研究，2015/01-2015/12，10萬元，已結題，主持

3. 國家自然科學基金面上項目，21075005，基于脲嘧啶和胸腺嘧啶五聯體的新型非共價自組裝體系的研究，2011/01-2013/12，35萬元，已結題，主持

4. 國家自然科學基金科學儀器基礎研究專項基金項目，20727002，噴霧輔助激光解吸環境電離源的設計、構建和基礎應用研究，2008/01-2010/12，160萬元，已結題，主持

5. 國家自然科學基金面上項目，20575006，電噴霧電離質譜方法在表面和生化分析中的應用基礎研究，2006/01-2008/12，28萬元，已結題，主持

代表性論文：

(1) Ran Qiu#, Xin Zhang#, Hai Luo*, Yuanhua Shao*, Mass spectrometric snapshots for electrochemical reactions, Chemical Science, 2016, 7(11): 6684-6688.

(2) Ran Qiu, Jiamu Sun, Chengsen Zhang*, Hai Luo*, Heterogeneous cation induced clusters formed at surfaces of micro-droplets, RSC Advances, 2016, 6(53): 47997-48000.

(3) Ran Qiu, Chengsen Zhang*, Zhen Qin, Hai Luo*,A multichannel rotating electrospray ionization mass spectrometry (MRESI): instrumentation and plume interactions, RSC Advances, 2016, 6(43): 36615-36622.

(4) Ran Qiu#, Jiamu Sun#, Xin Zhang, Wenbo Zhao, Zhen Qin*, Hai Luo*, Isomer differentiation through supramolecular self-assembly in microdroplets of milliseconds life-time, Analyst, 2016, 141(5): 1641-1644.

(5) Ran Qiu, Hai Luo*, Copper (I)-triazole dimer formation and rate acceleration in in-source click reaction, RSC Advances, 2015, 5(116): 96213-96221.

(6) 任昕昕, 邱然, 羅海*,高電壓輔助激光解吸附離子化質譜中鹽效應的研究, 分析化學，2014，42(11): 1697-1701.

(7) Wenbo Zhao, Zhen Qin, Chengsen Zhang, Meiping Zhao*, Hai Luo*, A label-free double amplification system for sensitive detection of single-stranded DNA and thrombin by liquid chromatography-mass spectrometry, Chemical Communications, 2014, 50(69): 9846-9848.

(8) Ran Qiu, Hai Luo*, Reaction and detection click in high-voltage assisted laser desorption ionization mass spectrometry, Analyst, 2014, 139(15): 3706-3708.

(9) Jiamu Sun, Zhen Qin, Jia Liu, Chengsen Zhang, Hai Luo*, Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry, Analyst, 2014, 139(12): 3154-3159.

(10) Zhen Qin, Bo Qiu, Jiamu Sun, Wenbo Zhao, Hai Luo*, Protonated primary amines induced thymine quintets studied by electrospray ionization mass spectrometry and density functional theory calculations, Journal of Mass Spectrometry, 2014, 49(4): 266-273.

(11) Xinxin Ren, Jia Liu, Chengsen Zhang, Jiamu Sun, Hai Luo*, Signal enhancement of carboxylic acids by inclusion with β-cyclodextrin in negative high-voltage-assisted laser desorption ionization mass spectrometry, Rapid Communications in Mass Spectrometry, 2014, 28(1): 115-122.

(12) Xinxin Ren, Jia Liu, Chengsen Zhang, Hai Luo*, Direct analysis of samples under ambient condition by high-voltage assisted laser desorption ionization mass spectrometry in both positive and negative ion mode, Rapid Communications in Mass Spectrometry, 2013, 27(5): 613-620.

(13) Jia Liu, Chengsen Zhang, Jiamu Sun, Xinxin Ren, Hai Luo*, Laser desorption dual-spray post-ionization mass spectrometry for direct analysis of samples via two informative channels, Journal of Mass Spectrometry, 2013, 48(2): 250-254.

(14) REN Xin-Xin, LIU Jia, ZHANG Cheng-Sen, LUO Hai*, Rapid and direct analysis of active ingredients in tablets using atmospheric pressure laser desorption ionization mass spectrometry, Chinese Journal of Analytical Chemistry, 2013, 41(3): 366-370.

(15) Zhen Qin, Jia Liu, Bo Qiu, Hai Luo*, Reactive desorption electrospray ionization mass spectrometry of self-assembled quintets of uracil and its homologues, Journal of Mass Spectrometry, 2012, 47(5): 552-554.

(16) Jia Liu, Chengsen Zhang, Jiamu Sun, Hai Luo*, Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry, Analyst, 2012, 137(8): 1764-1767.

(17) Bo Qiu, Zhen Qin, Jia Liu, Hai Luo*, Thymine quintets and their higher order assemblies studied by electrospray ionization mass spectrometry and theoretical calculation, Journal of Mass Spectrometry, 2011, 46(6): 587-594.

(18) Congfang Lai, Guangxin Lin, Wenyue Wang, Hai Luo*, Absolute configurations and stability of cyclic guanosine mono-adducts with glyoxal and methylglyoxal, Chirality, 2011, 23(7): 487-494.

(19) Jia Liu, Bo Qiu, Hai Luo*, Fingerprinting of yogurt products by laser desorption spray post-ionization mass spectrometry, Rapid Communications in Mass Spectrometry, 2010, 24(9): 1365-1370.

(20) Guangxin Lin, Jing Zhang, Yu Zeng, Hai Luo*, Yinsheng Wang*, Conformation dependent formation of theG[8-5]U intrastrand cross-link in 5-bromouracil-containing G-quadruplex DNA induced by UVA irradiation, Biochemistry, 2010, 49(11): 2346-2350.

(21) Bo Qiu, Jia Liu, Zhen Qin, Guanbo Wang, and Hai Luo*, Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry, Chemical Communications, 2009, (20): 2863-2865.

(22) Bo Qiu, and Hai Luo*, Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model, Journal of Mass Spectrometry, 2009, 44(5): 772-779.

(23) Congfang Lai, Huachuan Cao, John E. Hearst, Laurence Corash, Hai Luo*, and Yinsheng Wang*, Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation, Analytical Chemistry, 2008, 80(22): 8790-8798.

(24) 薛震，邱波，林廣欣，賴叢芳，羅海*,解吸電噴霧電離技術,化學進展, 2008, 20(4): 594-601.

已授權專利：

(1) 張成森，羅海，邱然，一種多通道旋轉萃取電噴霧離子化質譜分析離子源，2015.01.14，中國，ZL201210202005.3

(2) 張成森，羅海，多通道旋轉電噴霧離子化質譜分析離子源，2014.07.02，中國, ZL201110422357.5

(3) 張成森，羅海，劉佳，秦震，質譜多通道旋轉電噴霧離子源，2013.03.06，中國，ZL201110240135.1

(4) 張成森，羅海，任昕昕，劉佳，一種高壓輔助激光解吸離子化質譜分析離子源，2012.07.18，中國，ZL201120498921.7

(5) 張成森，羅海，秦震，劉佳，質譜雙離子源安裝平台裝置，2011.12.07，中國，ZL201120134522.2

(6) 羅海，劉佳，邱波，質譜離子傳輸管外延長接口裝置，2010.05.12，中國，ZL200920108393.2