陳家華

主講課程：

生物化學（化學院本科生課程）

研究領域和興趣：

化學基因組學是一門新興的交叉學科，是探索和理解重要生命過程的方法和手段。我們緻力于發展簡潔高效的、能有效實現化合物多樣性的組合合成研究；通過天然産物及其類似物的組合合成，進一步通過生物篩選來尋找和發現探索生命過程的小分子探針以及具有特定生物活性的藥物先導化合物。

代表性論文和專著：

1. Yefeng Tang, Yandong Zhang, Mingji Dai, Tuoping Luo, Lujiang Deng, Jiahua Chen*, and Zhen Yang*, A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the CO-Catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation, Org.Lett. 2005, 7, 885-888
2. Yandong Zhang, Yefeng Tang, Tuoping Luo, Juan Shen, Jiahua Chen*, and Zhen Yang*, Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A, Org. Lett. 2006, 8, 107-110
3. Zhibo Ma, Zheng Xiang, Tuoping Luo, Kui Lu, Zhibin Xu, Jiahua Chen*, Zhen Yang*, Synthesis of Functionalized Quinolines via Ugi and Pd-Catalyzed Intramolecular Arylation ReactionsJ. Comb. Chem. 2006; 8(5); 696-704.
4. Yongxiang Liu, Kui lu, Mingji Dai, Kai Wang, Wanqing Wu, Jiahua Chen* Junmin Quan* and Zhen Yang*, An Efficient One-pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions, Org. Lett, 2007, 9, 805-808
5. Yandong Zhang, Weiwu Ren, Yu Lan, Qing Xiao, Kai Wang, Jie Xu, Jiahua Chen*, and Zhen Yang*, Stereoselective Construction of an Unpricedented 7-8 Fused Ring System in Micrandilactone A by [3,3]-Sigmatropic Rearrangement, Org. Lett. 2008, 10, 665-668
6. Nengdong Wang, Jiang Xiang, Zhibo Ma, Junmin Quan, Jiahua Chen, and Zhen Yang, A Concise and Diversity-Oriented Apporach to the Synthesis of SAG Derivatives, J. Comb. Chem. 2008, 10, 825-834