研究室工作進展 July 23rd, 2009
Zirconocene-mediated ligand-switched selective cleavage of active and inert carbon-carbon bonds in allylcyclopropanes
Chao Wang, Liang Deng, Jun Yan, Hailin Wang, Qian Luo, Wen-Xiong Zhang and Zhenfeng Xi*
Chem. Commun., 2009, 4414-4416.
In this paper, we have developed a novel zirconium (II)-mediated ligand-controlled selective cleavage of different C–C bonds in bromoallylcyclopropane, which contains multiply reactive sites. This reaction represents a new way leading to selective cleavage of both reactive and inert C–C bonds.
本論文主要研究了低價有機锆試劑促進的多取代環丙烷的開環反應。在反應中對锆的配體進行調控後，惰性的環丙烷側鍊碳碳鍵可以被切斷，而活潑的三元母環卻可以保持。碳碳鍵活化以其重要性和高難度被稱為化學的聖杯。本部分的工作初步體現了一類新型的碳碳鍵活化過程。