報告人: Prof. JoAnne Stubbe

Novartis Professor of Chemistry

Professor of Biology

MIT

時　間：2018年9月21日(星期五)下午2:00

地　點：化學樓A204/206

主請人：鄒鵬

報告摘要：

In this talk, I will discuss the role of free radicals in biology, a problem that my lab has investigated for 30 years.  Ribonucleotide reductases (RNRs) are a group of enzymes that serve as a paradigm for Nature’s use of controlled radical chemistry.  In all organisms, these enzymes catalyze the conversion of nucleotides, the building blocks of RNA, to deoxynucleotides, the building blocks of DNA, and consequently supply the monomeric precursors required for DNA replication and repair.  While this chemical transformation, cleavage of a carbon-hydroxyl (C-OH) bond of one of four nucleotide substrates and formation of a carbon-hydrogen (C-H) bond, appears to be very “simple”, nothing could be farther from the truth. The central role of RNRs in nucleic acid metabolism has also made them the successful target of three drugs that are used clinically, including gemcitabine a mechanism based inhibitor rationally designed from our understanding of the mechanism of nucleotide reduction.

報告人簡介

JoAnne Stubbe教授是麻省理工學院化學系Novartis講席教授、美國科學院院士、美國藝術與科學學院院士。她于1968本科畢業于University of Pennsylvania，1971年在UC Berkeley獲博士學位，1987年起任MIT化學系教授，1990年兼任生物系教授。Stubbe教授的研究工作主要集中在闡明酶催化的化學機制。她在揭示核糖核苷還原酶的複雜反應機理方面取得一系列開創性進展，對于DNA在細胞中代謝的研究有着重要意義。由于這一突出貢獻，Stubbe教授于2009年獲得了國家科學獎章（National Medal of Science）。她還獲得過美國化學會的Nakanishi Prize（2009）和Remsen Award（2015），以及Welch award (2010)和Murray Goodman Memorial Prize（2010）等重大獎項。

JoAnne Stubbe obtained her Bachelor degree in Chemistry in 1968 from University of Pennsylvania. She then studied Organic Chemistry as a graduate student with George Kenyon at University of California Berkeley, and obtained her Ph.D in 1971. After graduation, she became an Assistant Professor of Chemistry at Williams College from 1971 to 1975. Then she worked Robert Abeles at Brandeis University as a Postdoctoral Fellow from 1975 to 1977. She In 1977, she joined Yale University School of Medicine as an Assistant Professor of Pharmacology. In 1980, she moved to University of Wisconsin, Madison, where she was promoted to Full Professor, and stayed until 1987. After that, JoAnne moved to MIT and became Novartis Professor of Chemistry and Professor of Biology.

歡迎參加！