姓名：郝偉
專業：有機化學
研究方向：有機反應動力學
電子信箱：weihao@scripps.edu
教育背景：
2011.9 – 2016.6, beat365官方网站，博士
導師：席振峰教授 張文雄教授
研究領域：環戊二烯膦配體在金屬有機化學中的應用及烷基鹵化钯中間體發生還原消除生成C(sp3)-X鍵的反應及其機理研究
研究經曆：
2021.7 – 2022.3, beat365官方网站，博士後
導師：席振峰教授 張文雄教授
2018.1 – 2021.7, The Scripps Research Institute,
Department of Chemistry, 博士後
導師: Prof. Donna G. Blackmond
導師: Prof. Donna G. Blackmond
研究領域：基于有機反應動力學研究多種類型反應機理（包括過渡金屬不對稱催化反應、氫化反應、電化學等）。在研究反應決速步過程中，建立動力學模型，研究活性催化劑物種 并提高催化效率，手性配體在反應過程中配體交換。通過核磁二維譜圖等手段分析活性中間體構型以及設計配體調節反應決速步。
2016.7 – 2017.12, Cornell University, Department of Chemistry and Chemical Biology, 博士後
導師: Prof. Song Lin
導師: Prof. Song Lin
研究領域：钛配合物催化的自由基反應（主要研究三元環與烯烴的環加成反應及其不對稱催化反應）
離組去向：中國科學院化學研究所 研究員
發表論文：
1. Wei Hao, Katherine L. Bay, Caleb F. Harris, Daniel S. King, Ilia A. Guzei, Michael M. Aristov, Zhe Zhuang, R. Erik Plata, David E. Hill, K. N. Houk, John F. Berry, Jin-Quan Yu, and Donna G. Blackmond, Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp3)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species.
ACS Catal. 2021, 11, 11040-11048.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
2. Yazhong Huang†, Kyle W. Knouse†, Shenjie Qiu†, Wei Hao‡, Natalia M. Padial‡ Julien C. Vantourout‡, Bin Zheng, Stephen E. Mercer, Javier O. Lopez, Rohan Narayan, Richard E. Olson, Donna G. Blackmond, Martin D. Eastgate, Michael A. Schmidt, Ivar M. McDonald, and Phil S. Baran, A P(V)-Platform for Oligonucleotide Synthesis.
Science, 2021 (accepted). (†, ‡Authors contributed equally.)
3. Yang Gao, David E. Hill, Wei Hao, Brendon J. McNicholas, Julien C. Vantourout, Ryan G. Hadt, Sarah E. Reisman, Donna G. Blackmond, and Phil S. Baran, Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism.
J. Am. Chem. Soc. 2021. 143, 9478-9488.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
4. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu, Pd-Catalyzed γ‑C(sp3)−H Fluorination of Free Amines.
J. Am. Chem. Soc. 2020, 142, 9966-9974.
5. Wei Hao, Johannes H. Harenberg, Xiangyu Wu, Samantha N. MacMillan, and Song Lin, Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.
J. Am. Chem. Soc. 2018, 140, 3514-3517.
6. Xiangyu Wu, Wei Hao, Ke-Yin Ye, Binyang Jiang, Gisselle Pombar, Zhidong Song, and Song Lin, Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors.
J. Am. Chem. Soc. 2018, 140, 14836-14843.
7. Qi Yang, Liang Liu, Yue Chi, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Rhodium-Catalyzed Intramolecular Carbosilylation of Alkynes via C(sp3)–Si Bond Cleavage.
Org. Chem. Front. 2018, 5, 860-863.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
8. Wei Hao, Xiangyu Wu, James Z. Sun, Juno C. Siu, Samantha N. MacMillan, and Song Lin, Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes.
J. Am. Chem. Soc. 2017, 139, 12141-12144.
9. Jianhao Yin, Qingyu Ye, Wei Hao, Shuaijing Du, Yucheng Gu, Wen-Xiong Zhang, and Zhenfeng Xi, Formation of Cyclopenta[c]pyridine Derivatives from 2,5-Disubstituted Pyrroles and 1,4-Dibromo-1,3-butadienes via Pyrrole-Ring One-Carbon Expansion.
Org. Lett. 2017, 19, 138-141.10. Wei Hao†, Junnian Wei†, Yue Chi, Patrick J. Walsh, Zhenfeng Xi, A DFT Study on Conversion of Aryl Iodides to Alkyl Iodides: Reductive Elimination of R–I from Alkylpalladium Iodide Complexes with Assesable b-Hydrogens.
Chem. Eur. J. 2016, 22, 3422-3429. (†Authors contributed equally.)
11. Wei Hao, Han Wang, Qingyu Ye, Wen-Xiong Zhang, and Zhenfeng Xi, Cyclopentadiene-Phosphine/Palladium Catalyzed Synthesis of Indolizines from pyrrole and alkenyl or aryl dibromides.
Org. Lett. 2015, 17, 5674-5677.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
12. Wei Hao, Han Wang, Patrick J. Walsh, and Zhenfeng Xi, Combining Pd (π-allyl) Cp and PPh3 as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp3)–I Reductive Elimination.
Org. Chem. Front. 2015, 2, 1080-1084.
13. Kunbing Ouyang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, Transition-Metal-Catalyzed Cleavage of C–N Single Bonds.
Chem. Rev. 2015, 115, 12045-12090.
14. Wei Hao, Junnian Wei, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halide Containing syn-b-Hydrogens.
Angew. Chem. Int. Ed. 2014, 53, 14533-14537.
15. Wei Hao, Weizhi Geng, Wen-Xiong Zhang, and Zhenfeng Xi, Palladium-Catalyzed One-Pot Three- or Four-Component Coupling of Aryl Iodides, Alkynes, and Amines through C-N Bond Cleavage: Efficient Synthesis of Indole Derivatives.
Chem. Eur. J. 2014, 20, 2605-2612.
16. Weizhi Geng, Chao Wang, Jie Guang, Wei Hao, Wen-Xiong Zhang, and Zhenfeng Xi, 1,2,3,4-Tetrasubstituted Cyclopentadienes and Their Applications for Metallocenes: Efficient Synthesis through Zirconocene- and CuCl-Mediated Intermolecular Coupling of Two Alkynes and One Diiodomethane.
Chem. Eur. J. 2013, 19, 8657-8664.
17. Weizhi Geng, Wen-Xiong Zhang, Wei Hao, and Zhenfeng Xi, Cyclopentadiene−Phosphine/Palladium-Catalyzed Cleavage of C−N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryl Dibromides.
J. Am. Chem. Soc. 2012, 134, 20230-20233.
